Tough stains and lingering odours are some of the most stubborn challenges in any home, especially in Canada, where over 60% of households now share their space with at least one pet. While traditional cleaners often rely on heavy perfumes to mask a smell, they frequently leave the root cause untouched. Enzyme cleaners work differently: they use biological catalysts to actually “digest” organic matter like proteins, starches, and oils, eliminating the mess at a molecular level.
The Canadian market is currently flooded with options, but not all formulas are created equal. Whether you’re dealing with a sudden pet accident on the rug, grass-stained hockey gear, or a musty basement drain, the right bottle can save you hours of scrubbing.
I’ve narrowed down the field to the 5 best enzyme cleaners available in Canada this year. I tested them based on their biological “horsepower,” scent profiles, and surface safety, so you can choose the best tool for your cleaning arsenal.
Our Top Picks:
- Best Overall: Angry Orange Odour Eliminator
Jump to Review - Runner-Up: Resolve Urine Destroyer Spray
Jump to Review - Best Value: ez-clean Advanced Odour Remover
Jump to Review - Best For Dogs: Nature’s Miracle Formula For Dogs
Jump to Review - Best Laundry Detergent: Active Enzyme Laundry Booster
Jump to Review
Top 5 Enzyme Cleaners in Canada in 2026
Best Overall: Angry Orange Odour Eliminator Concentrate
Originally developed for farms and industrial settings, Angry Orange has built a cult following among pet owners. Its citrus-based formula does more than just cover odours; it neutralizes them completely. Compared to milder options like Nature’s Miracle, Angry Orange has a sharper, more immediate impact on carpets, upholstery, and even outdoor turf.
The fresh orange scent is strong at first (some love it, others find it intense), but its ability to neutralize stubborn urine and feces odours makes it worth the hype. Unlike some cleaners that require repeated applications, a single treatment often does the job.
Why it’s great
- Powerful odour elimination (not just masking)
- Citrus scent that feels fresher than chemical cleaners
- Works on multiple surfaces indoors and outdoors
- Concentrated formula, so a little goes a long way
What can be improved
- Strong citrus scent may be overwhelming for sensitive noses
- More expensive than some alternatives
Runner-Up: Resolve Urine Destroyer Spray
Resolve Urine Destroyer earns its runner-up spot because of its balance between affordability and performance. It’s widely available in Canada (Home Depot, Walmart, RONA) and works well on carpets, fabric, hardwood, and tiles. The enzyme-powered formula neutralizes urine odours on contact and discourages pets from marking the same spot.
Compared to Angry Orange, Resolve’s scent is lighter and less citrus-heavy. It may not cut through extremely tough smells as aggressively, but for everyday pet messes, it’s a reliable and affordable solution.
Why it’s great
- Easily available across Canada
- Neutralizes odours and discourages re-marking
- Safe on multiple household surfaces
- Lighter scent than citrus-based cleaners
What can be improved
- May require multiple applications for severe messes
- Bottle nozzle could be sturdier
Best Value: ez-clean Advanced Odour Remover
Ez-clean is a Canadian-made, professional-strength enzyme cleaner trusted by kennels and groomers across the country. What sets it apart is its concentration; with 50 billion bioenzymes per litre, it can be diluted up to 1:64 and still outperform most household cleaners. Compared to Resolve or Nature’s Miracle, ez-clean is the heavy hitter that serious pet owners and professionals rely on.
Because it’s so concentrated, a single bottle lasts far longer than most competitors. It’s also versatile: from kennels to laundry, septic tanks to skunk spray, ez-clean is a multi-use powerhouse that goes beyond pet accidents.
Why it’s great
- Professional-grade strength, highly concentrated
- Made in Canada and tested in multi-dog facilities
- Effective on everything from kennels to laundry and septic tanks
- Extremely cost-effective when diluted
What can be improved
- Stronger learning curve for proper dilution
- Not as convenient as pre-mixed sprays
Best For Dogs: Nature’s Miracle Advanced
For dog owners, Nature’s Miracle is practically a household name. This enzymatic cleaner is formulated specifically for severe dog messes, including urine, diarrhea, and even vomit. It doesn’t just clean, it discourages re-soiling by breaking down the odour source. Compared to Resolve, it’s more pet-specific and continues working as long as the smell or stain remains.
At just over $10 for the spray bottle, it’s also one of the most affordable enzymatic cleaners on the Canadian market. The fresh scent is lighter than Angry Orange, making it a good choice for homes sensitive to strong fragrances.
Why it’s great
- Affordable and widely available in Canada
- Designed specifically for dog messes
- Discourages re-soiling by fully eliminating odour
- Available in multiple sizes
What can be improved
- Not suitable for untreated hardwood or specialty fabrics
- Requires blotting and patience for best results
Best Enzyme Detergent: Active Enzyme Laundry Booster
Sometimes the toughest odours and stains don’t happen on carpets, but on your clothing or linen. Active Enzyme Laundry Booster is designed as a detergent additive that supercharges your regular wash. Unlike basic detergents, its enzyme formula breaks down sweat, oil, food stains, and even lingering pet odours.
Compared to all-purpose sprays like Angry Orange or Resolve, this product shines because it targets clothes, bedding, and sports gear. It’s especially effective for households with athletes, medical scrubs, or stubbornly smelly laundry that just won’t freshen up with regular detergent.
Why it’s great
- Boosts regular laundry detergent for deeper cleaning
- Targets sweat, oils, and protein-based stains
- Works on athletic gear and uniforms
- Great for whitening and deodorizing
What can be improved
- Only for laundry use (not multipurpose like sprays)
- Slightly more expensive than standard boosters
What is an Enzyme Cleaner?
Enzyme cleaners are cleaning products that use naturally occurring bacteria and enzymes to break down organic matter such as urine, blood, sweat, food, and pet messes. Instead of masking odours with fragrance, they digest the organic source, leaving surfaces truly clean.
Unlike harsh chemical cleaners, enzyme cleaners are generally safer for pets, kids, and the environment, making them an eco-friendly and effective option for households dealing with stubborn stains.
What Are the Main Uses for Enzyme Cleaners?
Enzyme cleaners are versatile and can be used in many areas of daily life. Here are some common uses:
- Pet urine, feces, vomit, and odours
- Food and drink stains
- Sweat and body odour in clothing or sports gear
- Blood and other organic messes
- Stinky garbage cans and compost bins
- Septic systems and RV toilets
- Stubborn mildew and smoke smells
What Type of Enzyme Cleaner Do I Need?
The best enzyme cleaner depends on your specific needs. If you’re primarily cleaning up after pets, targeted sprays like Angry Orange, Resolve, or Nature’s Miracle are excellent. For multi-purpose, professional-grade cleaning, ez-clean is unmatched in versatility and concentration. And if your problem is laundry-based, the Active Enzyme Laundry Booster delivers the deepest clean.
Think about whether you want a ready-to-use spray for quick jobs, or a concentrated formula that can be diluted for larger-scale applications. Pet owners may even benefit from keeping more than one type on hand.
